Related Experiment Video

Updated: Jan 30, 2026

Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy
07:45

Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy

Published on: December 30, 2025

375

The Association Between Retinopathy of Prematurity and Ocular Growth

Dimitrios Kardaras1, Eleni Papageorgiou1, Katerina Gaitana2

  • 1Department of Ophthalmology, Medical School, University of Thessaly, Larissa, Greece.

Investigative Ophthalmology & Visual Science
|January 15, 2019
PubMed

Insights

Retinopathy of prematurity (ROP) in premature infants is linked to slower eye growth and development. Specific changes in axial length, corneal thickness, and weight gain can help predict ROP.

Area of Science:

  • Ophthalmology
  • Neonatology
  • Developmental Biology

Background:

  • Retinopathy of prematurity (ROP) is a significant cause of visual impairment in premature infants.
  • Understanding the relationship between ocular growth and ROP is crucial for early detection and intervention.

Purpose of the Study:

  • To prospectively investigate the association between retinopathy of prematurity (ROP) and ocular growth in premature infants.
  • To identify biometric parameters that can predict ROP development in early life.

Main Methods:

  • A prospective study involving 100 premature infants (gestational age 24-35 weeks).
  • Regular examinations recorded ROP status, axial length (AL), central corneal thickness (CCT), and weight gain using A-scan biometry.
  • Multiple regression analysis was used to determine associations between biometric variables and ROP.

Main Results:

  • Specific thresholds for weekly changes in AL (<0.095 mm increase), CCT (<0.5 μm reduction), and weight gain (<7%) were associated with ROP development.
  • Infants with ROP showed delayed ocular development, characterized by shorter AL and thicker CCT.

Conclusions:

  • ROP is associated with delayed ocular development in premature infants.
  • Axial length, corneal thickness, and weight gain are valuable indicators for predicting ROP.
  • These findings can inform the development of predictive models for ROP.
Abstract

More Related Videos

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model10:32

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model

Published on: April 2, 2021

4.2K
Application of Optical Coherence Tomography to a Mouse Model of Retinopathy08:22

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

5.2K

Related Concept Videos

Association Areas of the Cortex01:21

Association Areas of the Cortex

Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
9.3K
Associative Learning01:27

Associative Learning

Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
Classical conditioning, also known...
1.3K
Population Growth00:57

Population Growth

Population size is dynamic, increasing with birth rates and immigration, and decreasing with death rates and emigration. In ideal conditions with unlimited resources, populations can increase exponentially, which plots as a J-shaped growth rate curve of population size against time. This type of curve is characteristic of newly-introduced invasive species, or populations that have suffered catastrophic declines and are rebounding.
28.4K
Somatosensory, Motor, and Association Cortex01:23

Somatosensory, Motor, and Association Cortex

The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
2.7K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.7K
Meristems and Plant Growth02:36

Meristems and Plant Growth

Plants grow throughout their lives; this is called indeterminate growth, and it distinguishes plants from most animals. Although certain parts of plants stop growing (e.g., leaves and flowers), others grow continuously—like roots and stems.
49.5K