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Updated: Jan 30, 2026

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
Published on: March 14, 2019
Vancomycin use in surrounding patients during critical illness and risk for persistent colonization with
1Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA; Department of Infection Prevention & Control, NewYork-Presbyterian Hospital, New York, NY, USA.
Abstract:
The optimal duration of contact precautions for vancomycin-resistant enterococcus (VRE)-colonized patients is uncertain and individual patient characteristics alone may not predict risk of prolonged colonization. Using a cohort of adult patients who underwent testing for VRE at intensive care unit (ICU) admission, we tested the association between local (unit-level) vancomycin use and persistent colonization with VRE. Higher unit-level vancomycin use significantly prolonged VRE colonization (P=0.03) independent of patient-level vancomycin use and unit VRE density.
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