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Lipid- and polymer-based plexes as therapeutic carriers for bioactive molecules
Pravin Shende1, Narayan Ture1, R S Gaud1
1Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM'S NMIMS, V. L Mehta Road, Vile Parle (W), Mumbai, India.
International Journal of Pharmaceutics
|January 15, 2019
Summary
Lipoplexes and polyplexes offer advanced delivery of genetic material for treating diseases like cancer. These nanocarriers provide advantages over traditional methods, though further research is needed for widespread use.
Area of Science:
- Biotechnology
- Nanomedicine
- Gene Therapy
Background:
- Lipoplexes (nucleic acids complexed with lipids) and polyplexes (nucleic acids complexed with polymers) are emerging nanocarriers.
- These complexes are investigated for delivering active and genetic materials for various medical conditions.
Purpose of the Study:
- To comparatively review lipoplexes and polyplexes.
- Focus on molecular structure, cellular transport, and formulation aspects.
Main Methods:
- Review of existing literature on lipoplexes and polyplexes.
- Comparative analysis of their properties and applications.
Main Results:
- Lipoplexes and polyplexes offer non-immunogenic viral gene transfer and facile manufacturing compared to conventional liposomes.
- They enhance DNA transfection via electrostatic interactions and are cost-effective.
- Applications include treatment for cancer and genetic disorders.
Conclusions:
- Lipoplexes and polyplexes show significant promise for gene delivery and therapeutic applications.
- Further research is essential for quality control, toxicity assessment, and optimized preparation methods for commercialization.
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