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Updated: Jan 30, 2026

Immunofluorescence to Monitor the Cellular Uptake of Human Lactoferrin and its Associated Antiviral Activity Against the Hepatitis C Virus
06:28

Immunofluorescence to Monitor the Cellular Uptake of Human Lactoferrin and its Associated Antiviral Activity Against the Hepatitis C Virus

Published on: October 1, 2015

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[4 years of direct-acting antivirals (DAAs) in the German Hepatitis C-Registry (DHC-R)]

Dietrich Hüppe1, Yvonne Serfert2, Peter Buggisch3

  • 1Gastroenterologische Gemeinschaftspraxis Herne, Herne.

Zeitschrift Fur Gastroenterologie
|January 15, 2019
PubMed
Abstract

Insights

The German Hepatitis C Registry (DHC-R) shows new antiviral treatments for chronic hepatitis C are highly effective and safe in real-world German patient care. Registry data confirms excellent tolerability and sustained virological response rates.

Area of Science:

  • Hepatology
  • Virology
  • Public Health

Background:

  • Chronic hepatitis C affects over 250,000 individuals in Germany.
  • Recent approval of potent direct-acting antiviral drugs has transformed treatment landscapes.
  • The German Hepatitis C-Registry (DHC-R) was established to monitor patient care and treatment outcomes.

Purpose of the Study:

  • To describe the epidemiology of hepatitis C in Germany.
  • To evaluate patient care patterns for chronic hepatitis C.
  • To assess the real-world efficacy and safety of newly approved antiviral therapies.

Main Methods:

  • Prospective, multicenter, non-interventional registry study across 327 German centers.
  • Documentation of all approved hepatitis C treatment options.
  • Analysis divided into four distinct time phases from February 2014 to July 2018.

Main Results:

  • Over 11,000 patients initiated antiviral treatment between 2014 and 2018.
  • Mean patient age decreased, while the proportion with a history of drug abuse increased.
  • Significant reduction in liver cirrhosis prevalence among treated patients.
  • Sustained virological response rates exceeded 94% with excellent tolerability.

Conclusions:

  • The DHC-R effectively reflects real-world hepatitis C patient management in Germany.
  • The registry provides valuable insights into evolving hepatitis C epidemiology.
  • Novel antiviral treatments demonstrate high efficacy and safety in clinical practice.

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