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[Effect of Astragalus membranaceus on Peripheral Blood Th17 in Patients with Allergic Rhinitis]

Cheng Zhang, Ping Wei, Wei Kou

    Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine
    |January 15, 2019
    PubMed

    Insights

    Astragalus membranaceus (AM) may help control allergic rhinitis (AR) by reducing helper T cell 17 (Th17) activation. High doses of AM significantly decreased Th17 cells and related factors in AR patients and healthy individuals.

    Area of Science:

    • Immunology
    • Pharmacology
    • Traditional Chinese Medicine

    Background:

    • Allergic rhinitis (AR) involves excessive helper T cell 17 (Th17) activation.
    • Astragalus membranaceus (AM) is a traditional Chinese medicine with potential anti-inflammatory properties.

    Purpose of the Study:

    • To investigate the effect of AM on Th17 cell expression and related factors in AR patients.
    • To explore the potential of AM in managing AR inflammation.

    Main Methods:

    • Peripheral blood mononuclear cells (PBMCs) from AR patients and healthy controls were treated with varying doses of AM.
    • mRNA expression of RORC (RORC), and protein levels of IL-17A and IL-22 were measured.
    • Th17 cell populations were quantified using flow cytometry.

    Main Results:

    • AR patients showed higher baseline levels of Th17, RORC mRNA, IL-17A, and IL-22 compared to controls.
    • High-dose AM significantly reduced RORC mRNA, Th17 cells, and associated cytokines in both AR and control groups.
    • Low-dose AM did not produce statistically significant changes.

    Conclusions:

    • Excessive Th17 activation is a key factor in AR pathogenesis.
    • AM demonstrates potential to inhibit AR inflammation by suppressing Th17 cell differentiation and cytokine release.

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