[Analysis of Animal Modeling Methods for Functional Dyspepsia]

Area of Science:

• Gastroenterology
• Traditional Chinese Medicine
• Pharmacology

Background:

• Functional dyspepsia (FD) is a prevalent clinical condition.
• FD encompasses symptoms like abdominal distension and epigastric pain, recognized in Traditional Chinese Medicine (TCM).
• Current animal models for FD lack standardization and may not fully capture the disease's complexity.

Purpose of the Study:

• To review and analyze existing methods for creating animal models of functional dyspepsia.
• To highlight the limitations of current FD animal models, particularly those based on Pi deficiency syndrome.
• To inform the development of more accurate and relevant FD animal models.

Main Methods:

• Literature review and analysis of published studies on functional dyspepsia animal modeling.
• Comparison of common FD animal models with the clinical presentation of FD and TCM syndromes.
• Evaluation of the suitability of Pi deficiency syndrome models for FD research.

Main Results:

• There is a lack of a unified standard for functional dyspepsia animal models.
• Pi deficiency syndrome models are frequently used but are not entirely equivalent to FD.
• Existing models require refinement to accurately reflect FD pathogenesis.

Conclusions:

• Developing standardized and validated animal models is essential for advancing functional dyspepsia research.
• Further investigation is needed to improve the accuracy and relevance of FD animal models.
• Better models will aid in understanding FD pathogenesis and developing effective treatments.