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Blood adiponectin concentration at birth in small for gestational age neonates: A meta-analysis

Eita Goto1

  • 1Department of Medicine and Public Health, Nagoya Medical Science Research Institute, Nagoya, Japan.

Diabetes & Metabolic Syndrome
|January 16, 2019
PubMed

Insights

Blood adiponectin concentration is lower in small for gestational age (SGA) neonates compared to healthy controls. This finding highlights potential early indicators for neonatal health and future metabolic risks in SGA infants.

Area of Science:

  • Neonatal Research
  • Endocrinology
  • Metabolic Health

Background:

  • Small for gestational age (SGA) neonates face higher risks of mortality and morbidity.
  • Adiponectin, a hormone from adipose tissue, plays a role in infant health and may predict adult metabolic complications.
  • Understanding adiponectin levels at birth in SGA infants is crucial for early intervention.

Purpose of the Study:

  • To investigate differences in blood adiponectin concentration at birth between SGA neonates and healthy controls.
  • To synthesize existing evidence on adiponectin levels in SGA neonates.

Main Methods:

  • A systematic literature search identified relevant English-language studies.
  • Study quality was assessed using the Newcastle-Ottawa Scale (NOS).
  • A meta-analysis was conducted to compare adiponectin levels between SGA neonates and controls.

Main Results:

  • Five high-quality studies involving 253 neonates were analyzed.
  • Blood adiponectin concentration was significantly lower in SGA neonates compared to healthy controls (P=0.016).
  • A moderate effect size (SMD=0.4-0.7) indicated a consistent difference.

Conclusions:

  • Neonates who are small for gestational age exhibit lower blood adiponectin concentrations at birth.
  • This finding suggests adiponectin may serve as a biomarker for SGA-related health risks.
  • Further research can explore the long-term implications of these lower adiponectin levels.
Abstract

Keywords:
AdiponectinBloodMeta-analysisSmall for gestational age

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