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A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
Published on: February 28, 2013
Glycemic profile assessment during betamethasone administration in women with gestational diabetes mellitus
Ioannis Kakoulidis1, Ioannis Ilias1, Anastasia Linardi1
1Department of Endocrinology, Diabetes and Metabolism, Elena Venizelou General and Maternity Hospital, Athens, Greece.
Aim:
Betamethasone's effect on glucose homeostasis in the presence of gestational diabetes has not been adequately investigated.
Materials-Methods:
We assessed the glycemic profile of 99 women with gestational diabetes (52 on insulin, 47 on medical nutrition therapy) who were given betamethasone during hospitalization for at risk pregnancies.
Results:
In insulin-treated women the increase in total daily insulin dose significantly linked to betamethasone dose (p = 0.014). In women on diet, the need for insulin was positively related to betamethasone dose, age and gestational age >34th week (all p < 0.05).
Conclusion:
Parsimonious betamethasone use might still be beneficial with a milder effect on glycemia.
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