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Updated: Jan 30, 2026
04:09
Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
Published on: March 3, 2023
3.7K
Topic platelet gel application in chronic diabetic foot ulcers
Marika Bini Antunes1, Lidia Costa1, Miguel Carneiro1
1Haematology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Diabetes & Metabolic Syndrome
|January 16, 2019
Summary
Homologous platelet gel effectively treats chronic diabetic foot ulcers, with 44% achieving complete healing. Patient compliance and glycemic control are crucial for successful outcomes in this therapeutic alternative.
Area of Science:
- Biomedical research
- Regenerative medicine
- Wound healing
Background:
- Chronic and recalcitrant diabetic ulcers pose a significant clinical challenge.
- Existing treatments often have limited efficacy for severe cases.
Purpose of the Study:
- To evaluate the effectiveness of homologous platelet gel in treating chronic diabetic ulcers.
- To assess factors influencing treatment outcomes.
Main Methods:
- Observational study over 45 months.
- Platelet gels derived from homologous platelet concentrates, activated with calcium gluconate.
- Application after ulcer debridement; evaluation of comorbidities, wound characteristics, and outcomes.
Main Results:
- 52 patients evaluated; 44% achieved complete healing, 7% partial improvement, 49% no progression.
- Common comorbidities included hypertension, dyslipidemia, and peripheral arteriopathy.
- No significant correlation between age or comorbidity number and response; favorable outcomes linked to compliance and glycemic control.
Conclusions:
- Homologous platelet gel represents an effective therapeutic option for chronic diabetic ulcers.
- Patient compliance and effective metabolic (glycemic) control are essential for successful treatment.
- Further research may explore optimizing patient selection and treatment protocols.
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