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Plasma endoglin in Type2 diabetic patients with nephropathy
Ahmed S Doghish1, Atef A Bassyouni2, Mohamed H Mahfouz2
1Biochemistry Department, Faculty of Pharmacy, Al-Azhar University, Nasr City, 13465, Cairo, Egypt; Biochemistry Department, Faculty of Pharmacy, Badr University in Cairo, Cairo, Egypt.
Diabetes & Metabolic Syndrome
|January 16, 2019
Summary
Plasma soluble endoglin (sEng) levels are elevated in type 2 diabetes patients, even before kidney damage is apparent. Increased sEng indicates disease progression and vascular abnormalities in diabetic nephropathy.
Area of Science:
- Endocrinology
- Nephrology
- Vascular Biology
Background:
- Diabetic nephropathy is a common diabetes mellitus complication.
- Endoglin, a TGF-β receptor component, is upregulated on endothelial cells during injury.
- Soluble endoglin (sEng) is a circulating form of endoglin.
Purpose of the Study:
- To measure plasma sEng levels in type 2 diabetes mellitus (T2DM) patients with and without nephropathy.
- To assess sEng as a potential biomarker for diabetic nephropathy progression.
Main Methods:
- Sixty-eight T2DM patients were categorized into normoalbuminuria and microalbuminuria groups, with a control group.
- Plasma sEng levels were quantified using ELISA.
- Fasting plasma glucose, HbA1c, lipid profile, creatinine, and GFR were also assessed.
Main Results:
- Plasma sEng levels were significantly higher in both T2DM groups compared to controls.
- sEng levels showed a significant positive correlation with HbA1c, HDL-C, and urinary albumin concentration in the normoalbuminuria group.
- sEng levels were slightly lower in the microalbuminuria group compared to the normoalbuminuria group, but this difference was not significant.
Conclusions:
- Elevated plasma sEng precedes endothelial dysfunction in T2DM.
- Increasing sEng levels correlate with diabetic nephropathy progression and vascular abnormalities.
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