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Updated: Jan 30, 2026

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RCBTB1 Deletion Is Associated with Metastatic Outcome and Contributes to Docetaxel Resistance in

Olivier Mauduit1,2,3, Céline Brulard1,3, Tom Lesluyes1,4

  • 1Inserm U1218, Bergonié Cancer Institute, F-33076 Bordeaux, France.

Cancers
|January 16, 2019
PubMed

Insights

RCC1 And BTB Domain Containing Protein 1 (RCBTB1) loss is common in metastatic sarcomas. Low RCBTB1 expression predicts poor chemotherapy response and metastasis in sarcoma patients, highlighting it as a potential therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Soft-tissue sarcomas with complex genomics lack specific genetic alterations and are treatment-resistant.
  • Identifying novel therapeutic targets is crucial for improving outcomes in these challenging cancers.

Purpose of the Study:

  • To identify common molecular pathways and potential therapeutic targets in sarcomas with complex genomics.
  • To investigate the role of the cell cycle gene RCBTB1 in sarcoma development and treatment response.

Main Methods:

  • Genomic and transcriptomic profiling of 106 sarcomas.
  • Retrospective analysis of three sarcoma cohorts.
  • In vitro and in vivo functional studies using leiomyosarcoma cells and xenografts.

Main Results:

  • RCBTB1 (RCC1 And BTB Domain Containing Protein 1) was identified as frequently lost or downregulated in metastatic sarcomas (62.5%) compared to non-metastatic ones (34%).
  • Low RCBTB1 expression correlated with metastatic progression in patients receiving chemotherapy.
  • RCBTB1 overexpression sensitized leiomyosarcoma cells to docetaxel, increasing apoptosis and mitotic rate, while inhibition had opposite effects.

Conclusions:

  • RCBTB1 deletion and downregulation are frequent in complex genomic sarcomas.
  • Reduced RCBTB1 expression is a prognostic marker for chemotherapy resistance and metastatic progression in sarcoma patients.
  • RCBTB1 modulates sensitivity to docetaxel, suggesting its potential as a therapeutic target for overcoming treatment resistance.
Keywords:
RCBTB1cancerdocetaxelpleomorphic sarcomasarcoma with complex genomics

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