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miRNA Polymorphisms and Risk of Cardio-Cerebrovascular Diseases: A Systematic Review and Meta-Analysis

Milad Bastami1, Jalal Choupani2, Zahra Saadatian3

  • 1Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz 5166614766, Iran. mi.bastami@live.com.

International Journal of Molecular Sciences
|January 16, 2019
PubMed

Insights

MicroRNA (miRNA) polymorphisms play a role in cardio-cerebrovascular diseases (CCDs). Specifically, miR-146a rs2910164 and miR-499 rs3746444 are associated with increased CCD risk, particularly coronary artery disease.

Area of Science:

  • Genetics
  • Cardiology
  • Neurology

Background:

  • MicroRNAs (miRNAs) are increasingly recognized for their role in cardio-cerebrovascular diseases (CCDs).
  • Associations between miRNA polymorphisms and CCD risk require comprehensive evaluation due to inconclusive prior studies.

Purpose of the Study:

  • To conduct a systematic review and meta-analysis on the association between miRNA polymorphisms and CCD susceptibility.
  • To clarify the role of specific miRNA polymorphisms in the risk of developing CCDs.

Main Methods:

  • Systematic literature search of PubMed, Embase, Scopus, and Web of Science.
  • Meta-analysis of eligible studies using odds ratios and 95% confidence intervals.
  • Evaluation of 31 miRNA polymorphisms across 51 articles, with detailed analysis of six polymorphisms.

Main Results:

  • Six miRNA polymorphisms were meta-analyzed; miR-146a rs2910164, miR-149 rs2292832, miR-149 rs71428439, miR-196a2 rs11614913, and miR-218 rs11134527 showed no association with overall CCD risk.
  • miR-499 rs3746444 was significantly associated with CCD risk.
  • Subgroup analyses indicated rs2910164 and rs3746444 were specifically linked to cardiovascular diseases (CVDs), especially coronary artery disease (CAD).

Conclusions:

  • The findings suggest that miR-146a rs2910164 and miR-499 rs3746444 may influence susceptibility to CCDs.
  • These specific miRNA polymorphisms, particularly miR-499 rs3746444, are implicated in the risk of developing CAD.

Keywords:
cardiovascular diseasecerebrovascular diseasecoronary artery diseaseischemic strokemeta-analysismicroRNApolymorphism

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