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09:02
Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
22.4K
Chronic lymphocytic leukaemia masquerading as a labial lump
Wei How Lim1,2, Eleni Mayson2,3, Vincent P Lamaro1,2,4
1Department of Gynaecology, St Vincent's Hospital, Darlinghurst, New South Wales, Australia.
BMJ Case Reports
|January 16, 2019
Summary
A genital lump in an 82-year-old woman was diagnosed as chronic lymphocytic leukemia (CLL). This rare presentation highlights the importance of considering CLL in extranodal sites, even with stable disease.
Area of Science:
- Oncology
- Hematology
- Gynecology
Background:
- Chronic lymphocytic leukemia (CLL) is a common B-cell malignancy in adults.
- Extranodal involvement of CLL is typically associated with disease progression.
- Genital involvement in CLL is uncommon, particularly in stable disease.
Observation:
- An 82-year-old woman with a history of stable CLL presented with a labial lump.
- The patient experienced hypogammaglobulinemia and recurrent infections, managed with intravenous immunoglobulin.
- A biopsy of the labial mass confirmed CLL infiltration.
Findings:
- The labial lump represented extranodal involvement of CLL.
- This finding occurred despite the absence of clinical evidence of disease progression.
Implications:
- This case underscores the potential for extranodal CLL presentation in the genital area.
- It emphasizes the need for thorough investigation of new masses in CLL patients, irrespective of overall disease status.
- Further research into the mechanisms and management of extranodal CLL is warranted.
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