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Paediatric case of peripapillary choroidal neovascularisation associated with optic disc drusen treated with
Weh Loong Gan1,2, Vernon W Long1,2
1The University of Leeds, Leeds, UK.
Insights
A rare complication in children, peripapillary choroidal neovascularisation (PPCNV) secondary to optic disc drusen, was successfully treated. Intravitreal aflibercept resolved vision loss and fluid, with no recurrence at follow-up.
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Medical Retina
Background:
- Optic disc drusen can rarely lead to peripapillary choroidal neovascularisation (PPCNV).
- PPCNV in children is a rare cause of severe vision impairment.
- This condition necessitates effective treatment strategies for pediatric patients.
Observation:
- A 6-year-old girl presented with acute vision loss in her right eye.
- Examination revealed bilateral optic disc elevation and subfoveal fluid on OCT.
- Findings were consistent with optic disc drusen and PPCNV.
Findings:
- The patient received three intravitreal aflibercept injections.
- Complete resolution of subfoveal fluid was observed post-treatment.
- Visual acuity improved significantly to 20/25 with no recurrence at 16 months.
Implications:
- Intravitreal aflibercept is a safe and effective treatment for pediatric PPCNV secondary to optic disc drusen.
- This case highlights a successful therapeutic approach for a rare but vision-threatening condition.
- Further research may explore aflibercept's role in similar pediatric retinal vascular disorders.
Abstract:
Peripapillary choroidal neovascularisation (PPCNV) associated with optic disc drusen is a rare complication that can result in severe vision impairment in children. We report the first case of paediatric PPCNV secondary to optic disc drusen successfully treated with intravitreal aflibercept. A 6-year-old girl presented with a one week history of reduced vision in her right eye with best-corrected visual acuity of 20/500. Fundus examination revealed bilateral elevated discs with a peripapillary pigmentary lesion in the right eye. Optical coherence tomography of the right eye showed marked subfoveal fluid. Both B-scan ultrasonography and fundus autofluorescence demonstrated findings consistent with optic disc drusen. Diagnosis of PPCNV was further confirmed on fluorescein fundus angiography. The child received three intravitreal aflibercept injections with complete resolution of the subfoveal fluid. Her visual acuity improved to 20/25 with no recurrence at a 16-month follow-up. No adverse side effects were reported.
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