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[Malaria in Switzerland].

M Fernex1

  • 1Recherche clinique, F. Hoffmann-La Roche & Cie SA, Bâle.

Schweizerische Medizinische Wochenschrift
|December 10, 1988
PubMed
Summary

Malaria affects Swiss travelers, with prompt treatment improving outcomes. Chemoprophylaxis, including mefloquine and Fansidar, is crucial for preventing severe falciparum malaria and atypical syndromes.

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Area of Science:

  • Tropical Medicine
  • Infectious Diseases
  • Public Health

Context:

  • Switzerland reports 200 malaria cases annually, but 2000-8000 travelers are infected abroad.
  • Prompt treatment initiation is vital, as delayed diagnosis in industrialized nations leads to higher mortality (1-4%).
  • Increasing chloroquine resistance necessitates alternative chemoprophylaxis strategies.

Purpose:

  • To review malaria chemoprophylaxis and treatment guidelines for travelers.
  • To highlight the importance of travel history in timely malaria diagnosis and treatment.
  • To discuss management of severe falciparum malaria and drug resistance.

Summary:

  • Severe falciparum malaria treatment involves quinine infusions followed by sulfadoxine, pyrimethamine, and mefloquine.
  • Mefloquine is recommended for chemoprophylaxis, especially with Fansidar resistance, with specific dosage regimens.
  • Reserve medications and combination therapies like Fansimef are evaluated for low-transmission risk scenarios.

Impact:

  • Effective chemoprophylaxis reduces the risk of malaria infection and atypical presentations like anemia and jaundice.
  • Guidelines emphasize prompt treatment and appropriate drug selection to improve patient prognosis.
  • HIV-positive individuals can travel safely to tropical regions with correct chemoprophylaxis.

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