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Updated: Jan 30, 2026
06:40
An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery
Published on: June 8, 2021
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[Laparoscopy combined with total intersphincteric resection for extremely low rectal cancer]
Zha Peng1, Jian Li1, Haibo Ding1
1Department of Hepatobiliary and Enteric Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Summary
Laparoscopy combined with total intersphincteric resection (Total-ISR) is a feasible surgical option for early-stage, extremely low rectal cancer, offering sphincter preservation and minimal invasion. This approach demonstrates effective oncologic outcomes and improves anal function over time.
Area of Science:
- Colorectal Surgery
- Surgical Oncology
- Minimally Invasive Procedures
Background:
- Extremely low rectal cancer presents unique surgical challenges, often requiring abdominoperineal resection.
- Sphincter-saving procedures are desirable to improve patients' quality of life.
Purpose of the Study:
- To evaluate the feasibility and therapeutic efficacy of laparoscopic surgery combined with total intersphincteric resection (Total-ISR).
- To assess oncologic outcomes and functional results for patients with extremely low rectal cancer.
Main Methods:
- A cohort of 45 patients with extremely low rectal cancer underwent laparoscopic Total-ISR.
- Data collected included operative time, blood loss, resection margins, complications, recurrence rates, metastasis, and anal function (Kirwan grade) at 3, 6, and 12 months post-surgery.
Main Results:
- All 45 operations were successful with no perioperative deaths. Mean operative time was 220±33 min, blood loss 110±31 mL, and all resection margins were negative.
- Postoperative complications occurred in 6.7% of patients, with no anastomotic leakage. Local recurrence and distant metastasis rates were low (2 and 1 case, respectively) after a median follow-up of 20.5 months.
- Significant improvements in anal function were observed between 3, 6, and 12 months post-operation (P<0.05).
Conclusions:
- Laparoscopic Total-ISR is a feasible and effective sphincter-saving procedure for select patients with early-stage extremely low rectal cancer.
- The technique offers advantages of minimal invasion, radical resection, and potentially better functional outcomes compared to traditional methods.
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