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Updated: Jan 30, 2026

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Cross metathesis-mediated synthesis of hydroxamic acid derivatives
Shital Kumar Chattopadhyay1, Subhankar Ghosh1, Suman Sil1
1Department of Chemistry, University of Kalyani, Kalyani - 741235, West Bengal, India.
Abstract:
An alternative synthesis of α,ß-unsaturated hydroxamates via cross metathesis between a class-I olefin and N-benzyloxyacrylamide is reported. The reaction proceeds better in the presence of Grubbs' second generation catalyst within short time and in good yields (57-85%) with a range of substrates. Subsequent hydrogenation of each of the CM products delivers the title compounds in moderate to very good yield (70-89%). An important demonstration of the protocol is the preparation of the unusual amino acid component of the bioactive cyclic peptide Chap-31.
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