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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
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Different notations are used to represent the three-dimensional structure of molecules on two-dimensional surfaces. One of the most commonly used representations is the dash-wedge formula. The dashed wedges, solid wedges, and the plane lines indicate the groups situated behind the plane, coming out of the plane, and in the plane, respectively.
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IR spectra are divided into two main regions: the diagnostic region and the fingerprint region. The diagnostic region of the spectrum lies above 1500 cm−1. The absorptions resulting from single-bond vibrations of the N–H, C–H, and O–H stretch at higher wavenumbers and appear on the left side of the spectrum. The stretching absorptions of the C≡C and C≡N occur between 2100–2300 cm−1. In contrast, those arising from stretching absorptions of the...
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Related Experiment Video

Updated: Jan 30, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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[ARENA-Project atrial fibrillation in the Rhein-Neckar region].

S Baumann1,2, A Grau3, J Senges4

  • 1I. Medizinische Klinik, Abteilung für Kardiologie, Pneumologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum Mannheim, DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Universität Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland.

Herz
|January 16, 2019
PubMed
Summary
This summary is machine-generated.

Atrial fibrillation (AF) affects many in the Rhein-Neckar region, increasing stroke risk. The ARENA project aims to improve AF awareness, diagnosis, and stroke prevention, particularly in diverse patient populations.

Keywords:
AnticoagulantsEpidemiologyMedicationRegistriesStroke

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Area of Science:

  • Cardiology
  • Public Health
  • Neurology

Background:

  • Atrial fibrillation (AF) is the most prevalent cardiac tachyarrhythmia.
  • An estimated 40,000-50,000 individuals in the Rhein-Neckar region are affected by AF.
  • Anticipated demographic shifts will lead to a significant increase in AF prevalence in coming decades.

Purpose of the Study:

  • To enhance awareness and care for patients with AF in the Rhein-Neckar region.
  • To reduce the incidence of stroke, a major complication of AF.
  • To investigate interventions, medication adherence, and the impact of migration background on AF patient care.

Main Methods:

  • The ARENA project involves collaboration between the IHF Ludwigshafen, local hospitals, physicians, and pharmacies.
  • Intervention subproject: Focuses on raising AF awareness and improving diagnostic work-up and patient care.
  • Medication and Migration subprojects: Assess adherence to antithrombotic therapy and evaluate care differences in patients with and without a migration background.

Main Results:

  • The project aims to improve the diagnostic work-up and care for AF patients.
  • It seeks to enhance adherence to prescribed antithrombotic medications.
  • Differences in care for patients with and without a migration background will be evaluated.

Conclusions:

  • The ARENA project is a multi-faceted initiative to improve AF patient outcomes and prevent stroke.
  • Enhanced awareness, better diagnostics, and optimized medication adherence are key goals.
  • Understanding the influence of migration background is crucial for equitable AF care.