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Epigenetic Regulation01:46

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Gene-Environment Interactions01:20

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Related Experiment Video

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An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling
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[Environment and epigenetics].

Elisabeth B Binder1,2

  • 1Abteilung für translationale Forschung für Psychiatrie, Max-Planck-Institut für Psychiatrie, Kraepelinstr. 2-10, 80804, München, Deutschland. binder@psych.mpg.de.

Der Nervenarzt
|January 16, 2019
PubMed
Summary
This summary is machine-generated.

Environmental factors significantly impact psychiatric disorders by causing lasting biological changes through epigenetic mechanisms. This review explores how these epigenetic changes mediate environmental risk and resilience, influencing psychiatric conditions and treatments.

Keywords:
Gene-environment interactionsMental disordersStressTherapeutic interventionsTrauma

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Environmental factors are key risk factors for psychiatric disorders.
  • Exposure to environments can induce lasting biological alterations.
  • Epigenetic mechanisms are central to embedding environmental risk factors.

Purpose of the Study:

  • To summarize epigenetic regulation levels.
  • To focus on mechanisms linking environmental signals to epigenetic changes.
  • To provide examples of environmentally induced epigenetic changes in psychiatric disorders.

Main Methods:

  • Review of epigenetic regulation.
  • Analysis of environmental signal transduction into epigenetic modifications.
  • Case examples of epigenetic changes and psychiatric outcomes.

Main Results:

  • Epigenetic mechanisms mediate the lasting impact of environmental exposures.
  • Environmentally induced epigenetic changes are linked to psychiatric disorder risk.
  • These changes also play a role in resilience and treatment response.

Conclusions:

  • Epigenetics provides a crucial link between environment and psychiatric disorders.
  • Understanding these mechanisms can inform treatment strategies.
  • Further research into environmentally induced epigenetic changes is warranted.