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Updated: Jan 30, 2026

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling
Published on: December 18, 2017
[Environment and epigenetics]
1Abteilung für translationale Forschung für Psychiatrie, Max-Planck-Institut für Psychiatrie, Kraepelinstr. 2-10, 80804, München, Deutschland. binder@psych.mpg.de.
Abstract:
Environmental factors are among the strongest risk factors for psychiatric disorders. Differences in exposure to such environments have been associated with lasting biological changes. In recent years epigenetic mechanisms have been brought to the forefront as central in mediating a lasting embedding of environmental risk factors. This article first summarizes the different levels of epigenetic regulation and then focuses on mechanisms transducing environmental signals into lasting epigenetic changes. This is followed by examples of how environmentally induced epigenetic changes relate to risk and resilience to psychiatric disorders and their treatment.
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