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Related Concept Videos

Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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IR Frequency Region: Fingerprint Region01:03

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IR spectra are divided into two main regions: the diagnostic region and the fingerprint region. The diagnostic region of the spectrum lies above 1500 cm−1. The absorptions resulting from single-bond vibrations of the N–H, C–H, and O–H stretch at higher wavenumbers and appear on the left side of the spectrum. The stretching absorptions of the C≡C and C≡N occur between 2100–2300 cm−1. In contrast, those arising from stretching absorptions of the...
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Anatomy of the Heart01:27

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The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
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The Eukaryotic Promoter Region02:40

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The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
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Region of Convergence01:17

Region of Convergence

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The z-transform is a powerful mathematical tool used in the analysis of discrete-time signals and systems. It is a crucial tool in the analysis of discrete-time systems, but its convergence is limited to specific values of the complex variable z. This range of values, known as the Region of Convergence (ROC), is fundamental in determining the behavior and stability of a system or signal. The ROC defines the region in the complex plane where the z-transform converges, which can take various...
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Regional Terms01:12

Regional Terms

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Regional terms describe anatomy by dividing the body parts into different regions that contain structures involved in contributing similar functions. Using these terms helps increase the accurate description and identification of the particular region of interest or region affected by the disease.
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Related Experiment Video

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High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning
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Region-resolved proteomics profiling of monkey heart.

Hao-Liang Hu1, Yu Kang2, Yong Zeng1

  • 1The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, China.

Journal of Cellular Physiology
|January 16, 2019
PubMed
Summary

This study profiled the monkey heart proteome, identifying over 3,200 proteins across vessels, valves, and chambers. This provides a crucial reference for understanding heart disease and discovering cardiac biomarkers in nonhuman primates.

Keywords:
bioinformatics analysisgene-disease associationsmonkey heartproteomics

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Area of Science:

  • Cardiovascular Proteomics
  • Nonhuman Primate Models
  • Biomedical Research

Background:

  • Nonhuman primates (NHPs) are vital in biomedical research due to human-like physiology.
  • Proteomics of the NHP heart is underexplored, limiting cardiac biomarker discovery.
  • Understanding NHP heart molecular characteristics is key for disease research.

Purpose of the Study:

  • To perform comprehensive proteomics profiling of the normal monkey heart.
  • To identify proteins and biological networks associated with cardiac function and disease.
  • To establish a reference map for NHP cardiac disease research and biomarker discovery.

Main Methods:

  • iTRAQ-coupled LC-MS/MS analysis of three distinct monkey heart regions (vessels, valves, chambers).
  • Identification and quantification of over 3,200 proteins.
  • Bioinformatics analyses including gene ontology, protein-protein interaction, and gene-disease association.

Main Results:

  • Over 3,200 proteins identified and quantified in the normal monkey heart.
  • Identified over 60 genes implicated in heart diseases like hypertrophic cardiomyopathy, heart failure, and myocardial infarction.
  • Enrichment analysis revealed key pathways including citrate cycle, amino acid degradation, and glycolysis.

Conclusions:

  • This study provides the first comprehensive proteomic map of the healthy monkey heart.
  • The identified proteins and pathways offer insights into cardiac disease pathogenesis.
  • This resource serves as a foundation for future NHP-based cardiac research and biomarker development.