Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bonding in Metals

Bonding in Metals

Metallic bonds are formed between two metal atoms. A simplified model to describe metallic bonding has been developed by Paul Drüde called the “Electron Sea Model”.

Coordination Compounds and Nomenclature

Coordination Compounds and Nomenclature

In most main group element compounds, the valence electrons of the isolated atoms combine to form chemical bonds that satisfy the octet rule. For instance, the four valence electrons of carbon overlap with electrons from four hydrogen atoms to form CH4. The one valence electron leaves sodium and adds to the seven valence electrons of chlorine to form the ionic formula unit NaCl (Figure 1a). Transition metals do not normally bond in this fashion. They primarily form coordinate covalent bonds, a...

Molecules and Compounds

Molecules and Compounds

Atoms and Molecules

Alkali Metals

Alkali Metals

Group 1 elements are soft and shiny metallic solids. They are malleable, ductile, and good conductors of heat and electricity. The melting points of the alkali metals are unusually low for metals and decrease going down the group, while the density increases going down the group with the exception of potassium (Table 1).
Table 1: Properties of the alkali metals

Ionic Compounds: Formulas and Nomenclature

Ionic Compounds: Formulas and Nomenclature

An element composed of atoms that readily lose electrons (a metal) can react with an element composed of atoms that readily gain electrons (a nonmetal) to produce ions through complete electron transfer. The compound formed by this transfer is stabilized by the electrostatic attractions (ionic bonds) between the oppositely charged ions.

Solubility of Ionic Compounds

Solubility of Ionic Compounds

Solubility is the measure of the maximum amount of solute that can be dissolved in a given quantity of solvent at a given temperature and pressure. Solubility is usually measured in molarity (M) or moles per liter (mol/L). A compound is termed soluble if it dissolves in water.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The evolving therapeutic landscape of gut-pancreatic peptide signalling in metabolic disorders: from mono- to multi-agonist therapies.

Bioscience reports·2026

Same author

Acute Effects of Cannabinoid Combination Therapies in a Western Diet-Induced Murine Model of Metabolic Liver Disease.

International journal of molecular sciences·2026

Same author

Xanthene-to-fluorene skeletal editing <i>via</i> oxygen deletion mediated by boron and aluminium radicals.

Chemical science·2026

Same author

Targeting the LPI/GPR55 Axis in MAFLD and MASH: Novel Insights, Therapeutic Strategies and Future Directions.

Liver international : official journal of the International Association for the Study of the Liver·2026

Same author

Cryo-Correlative Light and X-ray Microscopies: Expanding the Intracellular Chemical Map.

ACS nano·2026

Same author

Correlating luminescence and single-molecule magnetism for two series of heteroleptic lanthanoid complexes.

Dalton transactions (Cambridge, England : 2003)·2026

Search research articles

Related Experiment Video

Updated: Jan 30, 2026

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish

Published on: May 15, 2021

Metal-based antitumor compounds: beyond cisplatin.

Peter V Simpson¹, Nima Maheshkumar Desai², Ilaria Casari²

¹Department of Chemistry, Curtin Institute of Functional Molecules & Interfaces, Curtin University, Kent Street, Bentley, Western Australia 6102, Australia.

Future Medicinal Chemistry

|January 16, 2019

Summary

This summary is machine-generated.

Metal-based compounds are crucial in cancer chemotherapy. New research explores non-platinum agents to enhance drug specificity and overcome chemoresistance in aggressive tumors, improving treatment efficacy.

Keywords:

cancer chemoresistance chemotherapy cisplatin metal-based anticancer agents

More Related Videos

Dose Uptake of Platinum- and Ruthenium-based Compound Exposure in Zebrafish by Inductively Coupled Plasma Mass Spectrometry with Broader Applications

Dose Uptake of Platinum- and Ruthenium-based Compound Exposure in Zebrafish by Inductively Coupled Plasma Mass Spectrometry with Broader Applications

Published on: April 21, 2022

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles

Published on: June 28, 2021

Related Experiment Videos

Last Updated: Jan 30, 2026

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish

Published on: May 15, 2021

Dose Uptake of Platinum- and Ruthenium-based Compound Exposure in Zebrafish by Inductively Coupled Plasma Mass Spectrometry with Broader Applications

Dose Uptake of Platinum- and Ruthenium-based Compound Exposure in Zebrafish by Inductively Coupled Plasma Mass Spectrometry with Broader Applications

Published on: April 21, 2022

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles

Published on: June 28, 2021

Area of Science:

Oncology
Medicinal Chemistry
Pharmacology

Background:

While survival rates for some cancers exceed 80%, aggressive tumors like pancreatic and brain cancers have poor prognoses.
Chemoresistance significantly reduces treatment effectiveness and contributes to cancer recurrence.
Metal-based compounds are a vital class of anticancer drugs currently used in chemotherapy.

Purpose of the Study:

To review the application of metal-based small molecules in chemotherapy.
To highlight recent advancements in the field.
To discuss novel non-platinum agents and strategies for overcoming chemoresistance.

Main Methods:

Literature review of recent studies on metal-based chemotherapy agents.
Analysis of drug specificity and chemoresistance mechanisms.
Exploration of non-platinum-based drug development.

Main Results:

Metal-based compounds show promise in cancer treatment.
Non-platinum agents are emerging as alternatives to traditional platinum-based drugs.
Increased drug specificity is key to overcoming chemoresistance.

Conclusions:

Metal-based small molecules represent a significant area of cancer chemotherapy research.
Developing specific, non-platinum agents is crucial for improving outcomes in aggressive cancers.
Further research into overcoming chemoresistance is essential for advancing cancer treatment.