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Updated: Jan 30, 2026

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
Published on: May 15, 2021
Metal-based antitumor compounds: beyond cisplatin
Peter V Simpson1, Nima Maheshkumar Desai2, Ilaria Casari2
1Department of Chemistry, Curtin Institute of Functional Molecules & Interfaces, Curtin University, Kent Street, Bentley, Western Australia 6102, Australia.
Abstract:
Despite improvements in the 5-year survival rate to over 80% in cancers, such as Hodgkin lymphoma and testicular cancer, more aggressive tumors including pancreatic and brain cancer still have extremely low survival rates. The establishment of chemoresistance, responsible for the reduction in treatment efficiency and cancer relapse, is one possible explanation for this setback. Metal-based compounds, a class of anticancer drugs, are largely used in the treatment of cancer. Herein, we will review the use of metal-based small molecules in chemotherapy, focusing on recent studies, and we will discuss how new nonplatinum-based agents are prompting scientists to increase drug specificity to overcome chemoresistance in cancer cells.
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