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Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain
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Motor development in children with Dravet syndrome
Karen Verheyen1,2, Evi Verbecque1, Berten Ceulemans2
1Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine and Health Science, University of Antwerp, Antwerp, Belgium.
Developmental Medicine and Child Neurology
|January 16, 2019
Summary
Motor development is significantly delayed in most children with Dravet syndrome, particularly after age two. This motor delay progresses with age, highlighting the condition's impact on development.
Area of Science:
- Pediatric Neurology
- Developmental Neuroscience
- Genetics
Background:
- Dravet syndrome is a severe epilepsy of infancy with significant neurodevelopmental comorbidities.
- Motor development is a crucial aspect of early childhood development, and its delays can indicate underlying neurological issues.
Purpose of the Study:
- To characterize the trajectory of motor development in children diagnosed with Dravet syndrome.
- To identify the prevalence and progression of motor delays in this population.
Main Methods:
- Retrospective analysis of medical records from 43 children with confirmed Dravet syndrome.
- Assessment of gross motor milestones, motor age equivalents, and specific motor domains using standardized tests (e.g., Bayley Scales, Peabody Developmental Motor Scales).
Main Results:
- A significant delay in gross motor milestones like sitting and walking was observed.
- Motor age equivalents revealed delays in 29 out of 38 assessments, with all children over two years old showing delays.
- Both gross and fine motor skills were affected, with delays becoming more pronounced with age.
Conclusions:
- Motor development is substantially delayed in the majority of children with Dravet syndrome, especially beyond two years of age.
- The observed heterogeneity in early motor milestones underscores the diverse presentation of Dravet syndrome.
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