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Mon2 predicts poor outcome in ST-elevation myocardial infarction

E Shantsila1, A Ghattas2, H R Griffiths3

  • 1University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK.

Journal of Internal Medicine
|January 16, 2019
PubMed

Insights

Monocyte subset Mon2 predicts poor outcomes in ST-elevation myocardial infarction (STEMI) patients, including heart failure and major adverse cardiovascular events. Targeting Mon2 function may offer therapeutic potential for STEMI.

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Biochemistry

Background:

  • Limited data exist on human monocyte subsets in ST-elevation myocardial infarction (STEMI).
  • Understanding monocyte subset roles is crucial for predicting STEMI outcomes.

Purpose of the Study:

  • To investigate the relationship between monocyte subsets, their phagocytic and nuclear factor κB (NFκB) activity, and patient outcomes in STEMI.
  • To determine the prognostic value of monocyte subsets in STEMI.

Main Methods:

  • Flow cytometry was used to analyze monocyte subsets, phagocytic activity, and intracellular inhibitory κB kinase β (IKKβ) levels in 245 STEMI patients.
  • Median follow-up was 46 months.

Main Results:

  • Monocyte subset Mon2 (CD14++CD16+CCR2+) counts independently predicted major adverse cardiovascular events (MACE) and heart failure (HF).
  • Higher Mon2 counts were associated with lower ejection fraction post-STEMI.
  • Increased intracellular Mon2 IKKβ levels correlated with a lower occurrence of HF.

Conclusions:

  • Abnormal Mon2 characteristics are uniquely associated with poor outcomes in STEMI patients.
  • The relationship between Mon2 and HF occurrence is strongly linked to its functional status, suggesting potential therapeutic targets.
Abstract

Keywords:
ejection fractionmonocyte subsetsmyocardial infarctionphagocytosis

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