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Updated: Jan 30, 2026
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Myocardial Infarction and Functional Outcome Assessment in Pigs
Published on: April 25, 2014
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Mon2 predicts poor outcome in ST-elevation myocardial infarction
E Shantsila1, A Ghattas2, H R Griffiths3
1University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK.
Journal of Internal Medicine
|January 16, 2019
Summary
Monocyte subset Mon2 predicts poor outcomes in ST-elevation myocardial infarction (STEMI) patients, including heart failure and major adverse cardiovascular events. Targeting Mon2 function may offer therapeutic potential for STEMI.
Area of Science:
- Cardiovascular Medicine
- Immunology
- Biochemistry
Background:
- Limited data exist on human monocyte subsets in ST-elevation myocardial infarction (STEMI).
- Understanding monocyte subset roles is crucial for predicting STEMI outcomes.
Purpose of the Study:
- To investigate the relationship between monocyte subsets, their phagocytic and nuclear factor κB (NFκB) activity, and patient outcomes in STEMI.
- To determine the prognostic value of monocyte subsets in STEMI.
Main Methods:
- Flow cytometry was used to analyze monocyte subsets, phagocytic activity, and intracellular inhibitory κB kinase β (IKKβ) levels in 245 STEMI patients.
- Median follow-up was 46 months.
Main Results:
- Monocyte subset Mon2 (CD14++CD16+CCR2+) counts independently predicted major adverse cardiovascular events (MACE) and heart failure (HF).
- Higher Mon2 counts were associated with lower ejection fraction post-STEMI.
- Increased intracellular Mon2 IKKβ levels correlated with a lower occurrence of HF.
Conclusions:
- Abnormal Mon2 characteristics are uniquely associated with poor outcomes in STEMI patients.
- The relationship between Mon2 and HF occurrence is strongly linked to its functional status, suggesting potential therapeutic targets.
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