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An Immunocompetent Murine Model for Laser Interstitial Thermal Therapy of Glioblastoma

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Improved MR thermometry for laser interstitial thermotherapy.

Henrik Odéen¹, Dennis L Parker¹

¹Utah Center for Advanced Imaging Research, Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah.

Lasers in Surgery and Medicine

|January 16, 2019

Summary

Improved magnetic resonance temperature imaging (MRTI) protocols enhance precision for laser interstitial thermal therapy (LITT). New 2D and 3D methods offer better temperature measurement and coverage without increasing scan times.

Keywords:

laser interstitial thermal therapy magnetic resonance temperature imaging magnetic resonance thermometry proton resonance frequency shift

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Area of Science:

Medical Imaging
Interventional Radiology
Thermal Therapy Monitoring

Background:

Laser interstitial thermal therapy (LITT) requires precise temperature monitoring during procedures.
Current 2D magnetic resonance temperature imaging (MRTI) protocols have limitations in precision and coverage.
Development of advanced MRTI protocols is crucial for optimizing LITT efficacy and safety.

Purpose of the Study:

To develop and evaluate enhanced 2D and 3D MRTI protocols for LITT.
To improve temperature measurement precision and volumetric coverage compared to existing clinical protocols.
To utilize readily available pulse sequences and methods for rapid clinical translation.

Main Methods:

Investigated four 2D and four 3D MRTI protocols using multi-echo readouts, partial Fourier, and parallel imaging.
Employed readily available pulse sequences like Cartesian 2D/3D gradient recalled echo and echo planar imaging (EPI).
Conducted in vivo volunteer and phantom studies at 1.5T and 3T, assessing precision, accuracy, and image quality with different coil setups.

Main Results:

Improved 2D protocols achieved up to a twofold increase in MRTI precision within the same acquisition time.
3D EPI protocols offered comparable precision to 2D methods but with significantly larger field-of-view coverage.
Higher field strength (3T) and local receive coils demonstrated superior MRTI accuracy and precision.

Conclusions:

The developed 2D and 3D MRTI protocols significantly enhance precision or coverage for LITT monitoring.
These protocols maintain current acquisition times, facilitating straightforward clinical implementation.
The use of widely available techniques ensures rapid adoption across various MRI systems and field strengths.