Related Experiment Video
Updated: Jan 30, 2026

Alginate Encapsulation of Pluripotent Stem Cells Using a Co-axial Nozzle
Published on: July 2, 2015
Polypeptidic Micelles Stabilized with Sodium Alginate Enhance the Activity of Encapsulated Bedaquiline
Héctor Soria-Carrera1, Ainhoa Lucía2,3,4, Laura De Matteis5
1Instituto de Ciencia de Materiales de Aragón, CSIC-Universidad de Zaragoza and CIBER-BBN, C/ Mariano Esquillor s/n, 50018, Zaragoza, Spain.
Abstract:
The coating of polypeptidic micelles with sodium alginate is described as a strategy to improve the stability of micelles for drug delivery. Bedaquiline, approved in 2012 for the treatment of multidrug resistant tuberculosis, has been used as an example of hydrophobic drug to study the loading efficiency, the release of the encapsulated drug in different media, and the in vitro antimicrobial activity of the system. Alginate coating prevents the burst release of the drug from micelles upon dilution and leads to a sustained release in all tested media. In view of possible oral administration, the alginate coated micelles show better stability in gastric and intestinal simulated media. Notably, the encapsulated bedaquiline shows increased in vitro activity against Mycobacterium tuberculosis compared to free bedaquiline.
Related Concept Videos
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
RNA Stability
Nuclear Stability
To hold positively charged protons together...
Regulation of Sodium and Potassium
Sodium Regulation
Sodium ions make up approximately 90% of extracellular cations, with a normal blood plasma concentration of 136–148 mEq/L. A decrease in blood volume and pressure triggers the release of renin from granular cells in the juxtaglomerular complex (JGC), primarily...
Stability
The stability of an LTI system is determined by the roots of its characteristic equation, known as poles. A system is stable if it produces a bounded...
Roles of Electrolytes: Sodium and Potassium

