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Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
Published on: May 19, 2020
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The pathogenesis of tuberculous meningitis
Angharad Grace Davis1,2,3, Ursula Karin Rohlwink4, Alizé Proust1
1The Francis Crick Institute, Midland Road, London, United Kingdom.
Journal of Leukocyte Biology
|January 16, 2019
Summary
Tuberculosis (TB) is a global threat. Tuberculous meningitis (TBM), a severe brain infection, requires urgent attention due to high mortality and disability. This review covers M.tb
Area of Science:
- Neurology
- Infectious Diseases
- Immunology
Background:
- Tuberculosis (TB) is a significant global health issue.
- Tuberculous meningitis (TBM) is the most severe form of extrapulmonary TB, affecting the central nervous system (CNS).
- TBM is a medical emergency with high mortality and disability rates.
Purpose of the Study:
- To review the pathogenesis of tuberculous meningitis (TBM).
- To discuss factors influencing Mycobacterium tuberculosis (M.tb) dissemination and CNS entry.
- To explore the immune response, clinical manifestations, and research priorities for TBM.
Main Methods:
- Literature review of TB dissemination to the CNS.
- Analysis of M.tb virulence factors and host vulnerability.
- Discussion of immune responses and clinical presentations of TBM.
Main Results:
- M.tb invades the CNS through various mechanisms.
- Intracranial inflammation is induced by M.tb, involving peripheral and resident immune cells.
- Pathologic mechanisms can either contain TBM or lead to severe brain injury.
Conclusions:
- Understanding TBM pathogenesis is crucial for improving patient outcomes.
- Host-pathogen interactions and immune responses significantly impact TBM severity.
- Further research is needed to identify new therapeutic strategies and reduce TBM-related mortality and disability.
Keywords:
Th17 cellsT Lymphocytesendothelial cellsgranulocytesmicroglia cellsmonocytes/macrophagesmycobacterialmyeloid cellsneutrophilsMore Related Videos
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