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Assessing Disaster Resilience of Concrete with Titanium Dioxide Nanoparticles

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Titanium dioxide nanoparticle modified plasmonic interface for enhanced refractometric and biomolecular sensing.

Hui Zhang, Yaofei Chen, Hao Wang

|January 16, 2019

Summary

Titanium dioxide nanoparticles (TDNPs) enhance surface plasmon resonance (SPR) biosensor sensitivity. This novel TDNP-SPR sensor offers a label-free, cost-effective platform for rapid biochemical detection.

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Optical Trapping of Plasmonic Nanoparticles for In Situ Surface-Enhanced Raman Spectroscopy Characterizations

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Published on: June 23, 2022

Area of Science:

Nanotechnology
Biosensing
Surface Chemistry

Background:

Surface Plasmon Resonance (SPR) biosensors are crucial for label-free detection.
Enhancing SPR sensitivity often requires complex amplification steps.
Modifying the plasmonic interface is key to improving biosensor performance.

Purpose of the Study:

To develop and investigate a novel SPR biosensor utilizing a titanium dioxide nanoparticle (TDNP) overlayer.
To enhance the probing electric field intensity and detection sensitivity of SPR biosensors.
To establish a chemical-free and contamination-free interface modification approach for SPR sensors.

Main Methods:

Fabrication of an SPR biosensor with a TDNP overlayer.
Engineering the TDNP overlayer thickness by adjusting TiO2-ethanol dispersion concentration.
Characterization of the sensor's refractive index sensitivity using ethylene glycol and fetal bovine serum.

Main Results:

The TDNP overlayer significantly enhances SPR detection sensitivity due to its large surface area and high refractive index.
The highest refractive index sensitivity achieved was 2567.3 nm/RIU for ethylene glycol, a 38% improvement over conventional SPR sensors.
A 1.59-fold sensitivity enhancement was observed for fetal bovine serum detection.

Conclusions:

The TDNP-SPR sensor demonstrates superior sensitivity and performance compared to conventional SPR sensors.
The chemical-free and contamination-free interface modification is a significant advancement.
This TDNP-SPR sensor presents a promising platform for sensitive, cost-effective, and biocompatible biochemical detection.