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Updated: Jan 30, 2026

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes
Published on: June 27, 2025
Adverse Maternal Outcomes Associated with Uterine Extensions at the Time of Cesarean Delivery
Soha S Patel1, Nathanael C Koelper2, Sindhu K Srinivas1
1Department of Obstetrics and Gynecology, Maternal and Child Health Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Objective:
We sought to compare adverse maternal outcomes between women with and without a uterine extension at the time of cesarean.
Study Design:
We conducted a retrospective cohort study of women with and without a uterine extension during a primary low transverse cesarean of a full-term singleton gestation. The primary outcomes were (1) estimated blood loss (EBL) and (2) composite maternal morbidity (defined as ≥ 1 of the following: blood transfusion, endometritis, or readmission). Pearson's chi-square or Fisher's exact test was used to compare categorical data; Student's t-test or Mann-Whitney's U-tests was used for continuous data. Linear and logistic regressions were used to adjust for confounding factors.
Results:
There were 252 women included (126 with extension and 126 without an extension). Women with extensions had a higher EBL (1,038 vs. 832 mL, p < 0.001) and higher rate of the composite maternal morbidity (19.1 vs. 5.6%, p = 0.001). Additionally, women with extensions had an increased risk of postpartum hemorrhage ≥ 1 L (53.2 vs. 23.8%, p < 0.001) and 1.5 L (12.7 vs. 0%, p < 0.001) and were associated with prolonged length of hospital stay (29 vs. 17%, p = 0.04).
Conclusion:
Uterine extensions are associated with adverse maternal outcomes including higher EBL and increase in maternal morbidity.
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