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Natural Killer Cells and Current Applications of Chimeric Antigen Receptor-Modified NK-92 Cells in Tumor

Jianguang Zhang1, Huifang Zheng2, Yong Diao3

  • 1School of Medicine, Huaqiao University, Quanzhou 362021, Fujian, China. 1601116007@hqu.edu.cn.

International Journal of Molecular Sciences
|January 17, 2019
PubMed

Insights

Natural killer (NK) cells are key innate immune cells. This review highlights NK-92 and CAR-NK-92 cells for their significant roles and applications in tumor immunotherapy.

Area of Science:

  • Immunology
  • Cell Biology
  • Cancer Research

Background:

  • Natural killer (NK) cells are crucial innate immune cells with rapid cytotoxic capabilities against abnormal and infected cells.
  • Advancements in cell biology have led to the establishment of various NK cell lines for research and therapeutic development.
  • NK-92 cells are a prominent human NK cell line, widely utilized and approved for clinical applications.

Purpose of the Study:

  • To review established human NK cell lines and their biological characteristics.
  • To highlight the therapeutic potential and applications of NK-92 cells in cancer immunotherapy.
  • To discuss the advancements and antitumor effects of chimeric antigen receptor-modified NK-92 (CAR-NK-92) cells.

Main Methods:

  • Literature review of established human NK cell lines.
  • Analysis of biological characteristics of NK cell lines, focusing on NK-92.
  • Examination of preclinical and clinical data on NK-92 and CAR-NK-92 cell applications in tumor immunotherapy.

Main Results:

  • NK-92 cells are a well-characterized and clinically approved NK cell line.
  • CAR-NK-92 cells demonstrate potent antitumor activity, enhancing the therapeutic efficacy of NK cells.
  • Various NK cell lines offer distinct advantages for different research and therapeutic contexts.

Conclusions:

  • NK-92 and CAR-NK-92 cells represent promising tools for advancing tumor immunotherapy.
  • Further research into NK cell line applications can lead to novel cancer treatment strategies.
  • The clinical approval and demonstrated efficacy of NK-92 cells underscore their importance in the field.
Keywords:
NK-92chimeric antigen receptorimmunotherapynatural killer cell linetumor

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