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[Non-allergic eosinophilic rhinitis. From clinical diagnosis to pathogenic study]
D A Moneret-Vautrin1, M Wayoff, V Hsieh
1Service de Médecine D, Immunologie Clinique et Allergologie, CHU de Brabois, Vandoeuvre-les-Nancy.
Summary
Non-allergic rhinitis with eosinophilia syndrome (NARES) affects 15% of rhinitis patients, characterized by nasal eosinophilia. NARES may link vasomotor rhinitis to nasal polyposis, asthma, and aspirin intolerance.
Area of Science:
- Allergy and Immunology
- Otorhinolaryngology
Context:
- Non-allergic rhinitis with eosinophilia syndrome (NARES) is a significant condition, with nasal eosinophilia detected in 15% of rhinitis cases.
- Characterized by sneezing and watery rhinorrhea, NARES presents with 20-90% eosinophils in nasal secretions, while immunological tests remain negative.
Purpose:
- To explore the diagnostic criteria and potential implications of Non-allergic rhinitis with eosinophilia syndrome (NARES).
- To investigate the link between NARES, vasomotor rhinitis, nasal polyposis, asthma, and aspirin intolerance.
Summary:
- NARES diagnosis requires demonstrating nasal eosinophilia (20-90%) in the absence of allergic reactions.
- Tomodensitometry can reveal progression to sinonasal polyposis, and bronchial challenges may indicate hyper-reactivity.
Impact:
- NARES may represent a transitional stage between common rhinitis and more severe conditions like nasal polyposis with asthma.
- Further research into eosinophil characteristics in NARES patients is crucial for understanding disease mechanisms and developing targeted therapies.