Related Experiment Video
Updated: Jan 30, 2026
09:19
Isolating Nasal Olfactory Stem Cells from Rodents or Humans
Published on: August 22, 2011
31.4K
Cysteinyl leukotriene 1 receptor expression in nasal polyps
Małgorzata Różańska1, Paweł Bielecki1, Joanna Reszeć2
1Uniwersytet Medyczny w Białymstoku Klinika Otolaryngologii.
Otolaryngologia Polska = the Polish Otolaryngology
|January 17, 2019
Summary
Cysteinyl leukotrienes (CysLTs) play a role in chronic rhinosinusitis (CRS). Higher CysLT1 receptor expression in nasal polyps of CRS patients, especially those with allergies, suggests CysLTs are key in CRS pathogenesis.
Area of Science:
- Immunology
- Otolaryngology
- Pathophysiology
Background:
- Cysteinyl leukotrienes (CysLTs) are implicated in chronic rhinosinusitis (CRS) pathogenesis.
- Understanding CysLT1 receptor expression is crucial for CRS research.
Purpose of the Study:
- To assess CysLT1 receptor expression patterns in CRS nasal polyps.
- To correlate CysLT1 receptor expression with clinical features of CRS.
Main Methods:
- Immunohistochemical evaluation of CysLT1 receptor expression.
- Comparison between 20 CRS patients with nasal polyps and 10 control subjects.
- Analysis of expression in relation to allergy status.
Main Results:
- Significantly higher CysLT1 receptor expression in CRS patients compared to controls (p<0.05).
- Tendency for higher expression in CRS patients with allergy (p=0.07).
- Significantly greater expression in CRS patients with drug allergy (p=0.03).
Conclusions:
- Elevated CysLT1 receptor expression in CRS nasal polyps indicates a role in disease pathogenesis.
- CysLTs may have a particular role in CRS with allergy, especially drug allergy.
More Related Videos
Related Concept Videos
01:19Antiasthma Drugs: Leukotriene Modifiers
1.8K
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
1.8K
01:28Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
619
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
619
01:31Internal Receptors
74.6K
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.6K
01:24Nose and Nasal Cavity
11.7K
The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
11.7K
01:29Administering Oxygen by Nasal Cannula
3.1K
Oxygen therapy is critical to patient care, especially for those struggling with respiratory issues. This intervention increases the oxygen concentration in the lungs, enhancing the amount of oxygen transported to the body's tissues. One standard method of delivering supplemental oxygen is through a nasal cannula, a non-invasive device that provides low to medium oxygen concentrations.
Nasal Cannulas
A nasal cannula is a lightweight tube split into two prongs placed in the nostrils,...
Nasal Cannulas
A nasal cannula is a lightweight tube split into two prongs placed in the nostrils,...
3.1K
01:39Receptor-mediated Endocytosis
110.9K
Overview
110.9K