Related Experiment Video

Updated: Jan 30, 2026

A Galleria mellonella Oral Administration Model to Study Commensal-Induced Innate Immune Responses
06:32

A Galleria mellonella Oral Administration Model to Study Commensal-Induced Innate Immune Responses

Published on: March 21, 2019

8.7K

Neonatal intestinal immune regulation by the commensal bacterium, P. UF1

Yong Ge1,2, Minghao Gong1,2, Natacha Colliou1,2

  • 1Department of Infectious Diseases & Immunology, University of Florida, Gainesville, FL, USA.

Mucosal Immunology
|January 17, 2019
PubMed

Insights

Propionibacterium strain P. UF1 enhances neonatal immunity by boosting protective Th17 cells and regulatory T cells (Tregs). This gut microbe protects newborn mice against intestinal Listeria monocytogenes infection.

Area of Science:

  • Immunology
  • Microbiology
  • Neonatal Health

Background:

  • Newborns possess immature immune systems, increasing susceptibility to infections.
  • Gut microbiota plays a crucial role in developing neonatal immunity.
  • Previous studies identified Propionibacterium strain P. UF1 as a Th17 cell inducer.

Purpose of the Study:

  • To investigate the immunomodulatory effects of P. UF1 in neonatal mice.
  • To evaluate P. UF1's protective capacity against intestinal pathogen infection.
  • To elucidate the mechanisms underlying P. UF1-mediated immune enhancement.

Main Methods:

  • Administration of P. UF1 to newborn mice.
  • Assessment of Th17 cell populations and regulatory T cells (Tregs).
  • Challenging mice with Listeria monocytogenes (L. m) infection.
  • Analysis of gut microbiota composition and B vitamin metabolites.
  • Transcriptomic analysis of P. UF1-induced Th17 cells.

Main Results:

  • P. UF1 significantly increased protective Th17 cells and IL-10+ Tregs in newborn mice.
  • P. UF1 conferred protection against intestinal L. m infection.
  • P. UF1 maintained gut microbiota homeostasis and induced beneficial B vitamin metabolites.
  • Transcriptomic data revealed key genes involved in Th17 cell differentiation and regulation.

Conclusions:

  • P. UF1 enhances neonatal host defense against intestinal pathogens.
  • P. UF1 modulates T cell immunity through microbiota and metabolite interactions.
  • P. UF1 shows potential as a probiotic for improving neonatal immunity.

More Related Videos

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model06:51

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model

Published on: July 28, 2023

1.8K
Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs06:25

Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs

Published on: March 5, 2016

10.0K

Related Concept Videos

Anatomy of the Intestines01:23

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
87.4K
What is the Immune System?01:38

What is the Immune System?

Overview
127.8K
Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.3K
Hormonal Regulation01:40

Hormonal Regulation

Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
48.1K
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.7K
GTPases and their Regulation02:14

GTPases and their Regulation

Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins,...
9.8K