Metabolism Plays a Key Role during Macrophage Activation
Related Experiment Video
Updated: Jan 30, 2026

Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes
Published on: March 28, 2025
Marion I Stunault1, Gaël Bories1, Rodolphe R Guinamard1
1Centre Méditerranéen de Médecine Moléculaire-Université Côte d'Azur-INSERM U1065, Team 13, France.
Abstract:
Monocyte and macrophage diversity is evidenced by the modulation of cell surface markers and differential production of soluble mediators. These immune cells play key roles in controlling tissue homeostasis, infections, and excessive inflammation. Macrophages remove dead cells in a process named efferocytosis, contributing to the healthy tissue maintenance. Recently, it became clear that the main macrophage functions are under metabolic control. Modulation of glucose, fatty acid, and amino acid metabolism is associated with various macrophage activations in response to external stimuli. Deciphering these metabolic pathways provided critical information about macrophage functions.
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