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Clinical-Morphological Aspects in Spinal Tuberculosis.

I Procopie1, E L Popescu1, R M Pleșea1

  • 1Doctoral School, University of Medicine and Pharmacy of Craiova, Romania.

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|January 17, 2019
PubMed
Summary
This summary is machine-generated.

This study assessed osteoarticular tuberculosis (OATB) in spinal tissue samples. Findings indicate that spinal tuberculosis (TB) requires thorough morphological investigation for prompt etiological diagnosis due to its severe potential.

Keywords:
BonesExtrapulmonary tuberculosisJointsSpine tuberculosis

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Area of Science:

  • Pathology
  • Orthopedics
  • Infectious Diseases

Background:

  • Osteoarticular tuberculosis (OATB) is a significant clinical concern.
  • Spinal tuberculosis (TB) poses life-threatening risks.
  • Accurate diagnosis is crucial for effective management.

Purpose of the Study:

  • To conduct a clinical morphological assessment of spinal tuberculous lesions.
  • To analyze tissue samples from patients diagnosed with spinal TB.
  • To correlate morphological findings with clinical data.

Main Methods:

  • Histological examination of bone, joint, and muscle tissue fragments.
  • Utilized Ziehl-Neelsen staining and immunohistochemistry for diagnosis.
  • Analyzed 7 cases from 54 patients investigated between 1990 and 2015.

Main Results:

  • Spinal TB predominantly affected men around 50 years old.
  • The thoracic spine was the most commonly involved segment.
  • Lesions showed epithelioid cells, giant Langhans cells, necrosis, and often disorganized granulomatous reactions with absent fibrosis.

Conclusions:

  • The clinical morphological profile aligns with existing literature.
  • Thorough investigation of spinal TB's morphological features is essential.
  • Rapid etiological diagnosis is critical for managing spinal tuberculosis.