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Cyclosporine-induced Erythromelalgia.

Lorin A Bibb1, Randi P Winter1, Stuart S Leicht1

  • 1Dermatology, East Tennessee State University Quillen College of Medicine, Johnson City, USA.

Cureus
|January 17, 2019
PubMed
Summary
This summary is machine-generated.

Erythromelalgia, a painful condition affecting extremities, can be triggered by medications. This case highlights cyclosporine as a reversible cause, emphasizing the need for thorough medication reviews in diagnosis.

Keywords:
cyclosporincyclosporinedistal extremitiesedemaerythemaerythermalgiaerythromelalgianeoralsecondary erythromelalgiavasodilation

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Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Erythromelalgia is a rare neurovascular disorder characterized by extremity pain, swelling, and warmth.
  • Primary erythromelalgia stems from SCN9A gene mutations, while secondary forms arise from various causes, including drug exposure.

Observation:

  • This report details a case of erythromelalgia potentially induced by oral cyclosporine.
  • The association between cyclosporine and erythromelalgia is infrequently documented in medical literature.

Findings:

  • Cyclosporine use was identified as a potential trigger for erythromelalgia symptoms.
  • The patient's symptoms resolved upon discontinuation of cyclosporine, indicating a reversible drug-induced condition.

Implications:

  • Physicians should consider drug-induced erythromelalgia in differential diagnoses.
  • Detailed medication histories, including inquiry about cyclosporine, are crucial for diagnosing and managing erythromelalgia.