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Homeostatic Imbalance01:10

Homeostatic Imbalance

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Homeostasis is the maintenance of a stable internal environment within the body, which is crucial for the proper functioning of cells, tissues, organs, and organ systems. The body has various control mechanisms that work together to regulate various physiological parameters such as temperature, blood pressure, pH balance, and fluid balance, to name a few. These control mechanisms are based on feedback loops that can be either positive or negative.
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Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
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Elements and Compounds01:27

Elements and Compounds

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Pure substances consist of only one type of matter. A pure substance can be an element or a compound. An element consists of only one type of atom, while a compound consists of two or more types of atoms held together by a chemical bond.
Elements
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The periodic table arranges atoms based on increasing atomic number so that elements with the same chemical properties recur periodically. When their electron configurations are added to the table, a periodic recurrence of similar electron configurations in the outer shells of these elements is observed. Because they are in the outer shells of an atom, valence electrons play the most important role in chemical reactions. The outer electrons have the highest energy of the electrons in an atom...
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Imbalances in Cardiac Output01:26

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The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
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Updated: Jan 30, 2026

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Trace Elements Homeostatic Imbalance in Psoriasis: a Meta-Analysis.

Wangqing Chen1, Xingchen Zhou2, Wu Zhu3

  • 1Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.

Biological Trace Element Research
|January 17, 2019
PubMed
Summary

Psoriasis patients show altered levels of trace elements, specifically higher zinc in lesions and higher serum copper. This suggests a potential homeostatic imbalance in copper and zinc, possibly offering new therapeutic targets for psoriasis.

Keywords:
CopperIronPsoriasisSeleniumTrace elementsZinc

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Area of Science:

  • Dermatology and Immunology
  • Trace Element Metabolism

Background:

  • Trace elements play crucial roles in immunological and inflammatory processes.
  • Previous research on trace elements and psoriasis has yielded controversial findings.

Purpose of the Study:

  • To investigate the association between psoriasis risk and four key trace elements: zinc (Zn), copper (Cu), iron (Fe), and selenium (Se).
  • To analyze existing literature and explore potential homeostatic imbalances in these elements in psoriasis patients.

Main Methods:

  • A comprehensive literature search was conducted across major scientific databases (PubMed, Embase, Cochrane Library, Google Scholar, Web of Knowledge).
  • A meta-analysis was performed on 42 identified studies to synthesize the data on trace element levels in psoriasis patients versus controls.

Main Results:

  • Serum levels of zinc, iron, and selenium did not show significant differences between psoriasis patients and control groups.
  • Psoriasis patients exhibited significantly higher levels of zinc within lesion tissues (SMD = 14.43, P < 0.0001).
  • Serum copper levels were also significantly higher in psoriasis patients compared to controls (SMD = 18.23, P = 0.007).

Conclusions:

  • The study indicates a homeostatic imbalance in copper and zinc levels in psoriasis patients.
  • These findings raise the possibility of targeting copper and zinc imbalances as a therapeutic strategy for managing psoriasis.