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Frontostriatal network dysfunction as a domain-general mechanism underlying phantom perception.

Jeffrey Hullfish1, Ian Abenes1, Hye Bin Yoo1

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|January 17, 2019
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Summary
This summary is machine-generated.

Chronic tinnitus involves altered brain connectivity in the nucleus accumbens (NAc) and frontostriatal networks. This abnormal functional connectivity correlates with tinnitus loudness and symptom duration in patients.

Keywords:
connectivityfMRInucleus accumbenspainphantom perceptiontinnitus

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Auditory Neuroscience

Background:

  • Tinnitus, or auditory phantom perception, is a prevalent condition affecting millions.
  • The underlying neural mechanisms of chronic tinnitus, particularly the role of specific brain networks, remain incompletely understood.

Purpose of the Study:

  • To investigate the involvement of the nucleus accumbens (NAc) and extended frontostriatal networks in tinnitus pathology.
  • To examine resting-state functional connectivity differences between chronic tinnitus patients and healthy controls.
  • To correlate functional connectivity patterns with clinical measures of tinnitus severity.

Main Methods:

  • Resting-state functional magnetic resonance imaging (fMRI) was employed.
  • Functional connectivity analysis focused on the NAc and frontostriatal networks.
  • A cohort of 90 chronic tinnitus patients and 94 healthy controls participated.

Main Results:

  • Patients with chronic tinnitus exhibited extensive functional connectivity involving the NAc, which was largely absent in healthy subjects.
  • NAc connectivity significantly correlated with tinnitus loudness and symptom duration, independent of age and hearing loss.
  • A specific loudness correlation involved the NAc and parahippocampal cortex, aligning with theories of tinnitus generation.

Conclusions:

  • Resting-state functional connectivity alterations in the NAc and frontostriatal networks are implicated in the pathology of chronic tinnitus.
  • These connectivity patterns may serve as biomarkers for tinnitus severity and potentially predict the transition from acute to chronic stages.
  • The findings suggest novel therapeutic targets within these identified neural circuits.