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Differential Expression of Fas in Moderate/Severe and Mild Persistent Allergic Rhinitis and Its Correlation With

Ashkan Pirayesh1, Shaghayegh Shahsavan1, Omid Zargari Samani1

  • 11 Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.

American Journal of Rhinology & Allergy
|January 17, 2019
PubMed
Abstract

Insights

Fas receptor expression on nasal turbinate mucosa is reduced in persistent allergic rhinitis (PAR) patients, particularly those with severe disease. This finding suggests a link between Fas levels and PAR severity.

Area of Science:

  • Immunology
  • Otorhinolaryngology
  • Allergy Research

Background:

  • The Fas receptor (Fas) and Fas ligand (FasL) interaction is crucial for immune tolerance.
  • Allergic rhinitis (AR) involves complex immune dysregulation.
  • Persistent AR (PAR) severity may be influenced by immune markers.

Purpose of the Study:

  • To evaluate Fas receptor expression in nasal inferior turbinate mucosa of patients with mild PAR and moderate to severe (M/S) PAR.
  • To determine the correlation between Fas expression levels and PAR disease severity.
  • To investigate the relationship between Fas production and allergic inflammation markers.

Main Methods:

  • Biopsies of nasal inferior turbinate mucosa were obtained from 70 M/S PAR patients, 70 mild PAR patients, and 70 healthy controls.
  • Fas mRNA expression was quantified using real-time polymerase chain reaction.
  • Fas protein presence and localization were assessed via immunohistochemistry; eosinophil counts, IgE levels, and Total Nasal Syndrome Score (TNSS) were also measured.

Main Results:

  • Fas expression was significantly decreased in M/S PAR patients compared to controls and mild PAR patients.
  • Local mucosal Fas expression showed a correlation with specific IgE levels, nasal eosinophil counts, and TNSS.
  • These findings indicate a potential role for Fas in the pathophysiology of PAR.

Conclusions:

  • A potential relationship exists between Fas receptor expression on nasal turbinate mucosa and the severity of persistent allergic rhinitis.
  • Reduced Fas expression may be associated with increased disease severity in PAR.
  • Further research is warranted to elucidate the precise role of Fas in PAR pathogenesis.
Keywords:
Fasallergic rhinitisimmunohistochemistrypathological parametersturbinate mucosa

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