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Analysis of Oxidative Stress in Zebrafish Embryos

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Oxidative Stress and Kidney Function: A Brief Update.

Giuseppe Coppolino^1,2, Giuseppe Leonardi², Michele Andreucci²

¹Nephrology and Dialysis Unit, "Pugliese-Ciaccio" General Hospital, Catanzaro, Italy.

Current Pharmaceutical Design

|January 17, 2019

Summary

This summary is machine-generated.

Oxidative stress, driven by reactive oxygen species (ROS), significantly impacts kidney function and chronic kidney disease (CKD) progression. This review highlights ROS

Keywords:

Oxidative stress carbohydrates cellular senescence chronic Kidney Disease (CKD)reactive oxygen species (ROS)renal function.

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Area of Science:

Nephrology
Biochemistry
Pathophysiology

Background:

The kidney is a primary site for reactive oxygen species (ROS) production.
ROS can damage cellular components, including proteins and DNA, leading to senescence and apoptosis.
Oxidative stress contributes to the harmful oxidation of lipids, proteins, carbohydrates, and nucleic acids in tissues.

Purpose of the Study:

To review the intricate link between kidney function and oxidative stress.
To elucidate the role of ROS in renal impairment and chronic kidney disease (CKD) pathogenesis.
To explore the impact of oxidative stress on systemic comorbidities during renal replacement therapies.

Main Methods:

Literature review of scientific articles and research findings.
Synthesis of evidence linking kidney physiology and oxidative stress.
Analysis of the pathophysiological mechanisms involved in renal oxidative damage.

Main Results:

The kidney plays a fundamental role in the production of reactive oxygen species (ROS).
Oxidative stress is implicated in the pathophysiology of renal impairment and mediates CKD progression.
Renal replacement therapies (hemodialysis, peritoneal dialysis) and transplantation expose patients to continued oxidative stress, increasing comorbidity risk.

Conclusions:

Oxidative stress is a critical factor in kidney disease development and progression.
Managing oxidative stress is essential for patients with kidney impairment and those undergoing renal therapies.
Reducing systemic oxidative burden may mitigate cardiovascular disease development in CKD patients.