Related Experiment Video

Updated: Jan 30, 2026

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
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Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

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Depression Rises the Risk of Hypertension Incidence: Discussing the Link through the Ca2+/cAMP Signalling

Leandro B Bergantin1

  • 1Department of Pharmacology-Escola Paulista de Medicina-Universidade Federal de Sao Paulo, Rua Pedro de Toledo, 669-Vila Clementino, Sao Paulo-SP, Postal Code: 04039-032, Brazil.

Current Hypertension Reviews
|January 17, 2019
PubMed

Insights

Depression and hypertension share a link through intracellular calcium (Ca2+) homeostasis dysregulation. Addressing depression is crucial for preventing and treating hypertension.

Area of Science:

  • Integrative biology
  • Cardiovascular research
  • Neuroscience

Background:

  • Depression and hypertension are prevalent global health issues with limited pharmacotherapies.
  • Intracellular calcium (Ca2+) homeostasis dysregulation is implicated in the pathogenesis of both conditions.
  • Depression is recognized as an independent risk factor for hypertension incidence.

Purpose of the Study:

  • To explore the cellular mechanisms linking depression and hypertension.
  • To discuss the potential role of Ca2+/cAMP signaling pathways in this association.

Main Methods:

  • Literature review focusing on Ca2+ and cAMP signaling pathways.
  • Analysis of existing data supporting the link between depression and hypertension.

Main Results:

  • Evidence suggests a dysregulation of intracellular Ca2+ homeostasis contributes to both depression and hypertension.
  • The Ca2+/cAMP signaling pathway is hypothesized to be involved in the interplay between these conditions.

Conclusions:

  • The Ca2+/cAMP signaling pathway may mediate the link between depression and hypertension.
  • Considering depression is vital for the prevention and treatment strategies of hypertension.
Abstract

Keywords:
Ca2+ homeostasisCa2+/cAMP signalingDepressionhypertensionpreventiontreatment.

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