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Updated: Jan 30, 2026
Extracting DNA from the Gut Microbes of the Termite Zootermopsis Angusticollis and Visualizing Gut Microbes
Published on: May 28, 2007
Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata
Mei-Chuan Chen1,2, Guei-Jane Wang3,4,5, Yueh-Hsiung Kuo6,7
1Graduate Institute of Pharmacognosy, Taipei, Taiwan.
Abstract:
Seven new isoprenyl phenolic ethers, namely fimbriethers A‒G (1‒7), were isolated from the fermented broth of the termite nest-derived medicinal fungus Xylaria fimbriata YMJ491. Their structures were determined by spectroscopic data analysis and compared with those reported. The effects of all the isolates at a concentration of 100 μM on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells were evaluated, and all of them exhibited NO production inhibitory activity with Emax values ranging from 4.6 ± 2.0% to 49.7 ± 0.5% without significant cytotoxicity. In addition, these seven compounds did not alter phenylephrine-induced vasocontraction in isolated intact thoracic aortic rings from C57BL/6J mouse, indicating 1‒7 were not involved in the regulation of endothelial NOS-mediated NO production.
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