Practical Aspects of Hyaluronic Acid Application in Biolevox HA Preparations - Report on Research

HA preparations in intraarticular injections have been applied in medicine since 1986 and became widely used in Poland at the beginning of the 90s of the twentieth century. Since then, numerous cases of successful application of intra-articular injections (the so called viscosupplementation) have been described in Polish and foreign literature. Changes in the molecular mass of hyaluronic acid and the related specific spatial structure result in different metabolic and immunological properties. Presently, in clinical practice, it is indicated to use the preparations produced by selected manufacturers who offer different forms of HA, containing different percentage of active substance (1 to 2.5%) and different molecular mass, making the desired number (1-5) of intra-articular injec-tions possible, depending on the type and intensity of a specific disease unit. Numerous studies have been con-ducted to confirm the effectiveness of treatment using hyaluronic acid. In Poland a research program was implemented to assess the practical application of 2 ml of Biolevox HA preparation in 2.2% concentration. During the study 15,000 patients were subjected to analysis. The physicians participating in the study injected the hyaluronic acid, in that case, Biolevox HA, to the knee joint, in patients with osteoarthritis, chondromalacia, knee joint injuries and other conditions.