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Updated: Jan 30, 2026

Reverse Microemulsion-mediated Synthesis of Monometallic and Bimetallic Early Transition Metal Carbide and Nitride Nanoparticles
Published on: November 27, 2015
Transition-Metal-Free Thioamination of Arynes Using Sulfenamides
Rahul N Gaykar1, Subrata Bhattacharjee1, Akkattu T Biju1
1Department of Organic Chemistry , Indian Institute of Science , Bangalore 560012 , India.
Abstract:
The insertion of arynes into the S-N σ-bond of sulfenamides allowing the synthesis of o-sulfanylaniline derivatives with reasonable functional group compatibility is presented. The aryne generated from 2-(trimethylsilyl)aryl triflates using CsF in DME was the key for the success of this transition-metal-free thioamination reaction, which involves new C-N and C-S bond formations in a single step under mild conditions. Moreover, the synthetic potential of this method was demonstrated by the synthesis of the antidepressant drug vortioxetine.
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