Related Experiment Video

Updated: Jan 30, 2026

A Traditional Chinese Medicine Characteristic Therapy for Bronchial Asthma: Moxibustion
05:56

A Traditional Chinese Medicine Characteristic Therapy for Bronchial Asthma: Moxibustion

Published on: May 12, 2023

5.2K

Precision medicine in childhood asthma

Elise M Slob1,2, Anke-Hilse Maitland-Van der Zee1,2, Gerard H Koppelman3,4

  • 1Department of Respiratory Medicine, Amsterdam University Medical Centers, University of Amsterdam.

Current Opinion in Allergy and Clinical Immunology
|January 17, 2019
PubMed

Insights

Precision medicine offers a tailored approach to childhood asthma management. Current strategies use clinical factors and biomarkers, with genomics and pharmacogenomics showing future potential for personalized asthma care.

Area of Science:

  • Pediatric Pulmonology
  • Precision Medicine
  • Asthma Research

Background:

  • Childhood asthma is a complex, heterogeneous condition often leading to uncontrolled disease.
  • An individualized treatment approach is crucial for improving asthma outcomes in children.
  • Current treatment selection based solely on clinical characteristics remains challenging.

Purpose of the Study:

  • To review the role of precision medicine in managing childhood asthma.
  • To explore the application of clinical characteristics, biomarkers, genomics, and pharmacogenomics for personalized asthma care.
  • To identify strategies for achieving asthma control and reducing risks with minimized side effects in children.

Main Methods:

  • Review of current clinical characteristics and biomarkers (eosinophils, IgE, FeNO) for asthma management.
  • Evaluation of novel monoclonal antibodies for severe, eosinophilic asthma.
  • Analysis of pharmacogenetic studies identifying risks associated with inhaled corticosteroids.

Main Results:

  • Monoclonal antibodies demonstrate efficacy in severe, eosinophilic asthma.
  • Reduced lung function growth and early decline are common in persistent childhood asthma.
  • Pharmacogenetic studies highlight risks of cortisol suppression with inhaled corticosteroids.

Conclusions:

  • Clinical characteristics and basic biomarkers can guide a foundational precision medicine approach.
  • Inhaled corticosteroids and biologics (omalizumab, mepolizumab) can be targeted using current precision methods.
  • Further research into pharmacogenomics and breathomics is needed for advanced precision medicine applications in pediatric asthma.
Abstract

More Related Videos

Acupuncture in a Rat Model of Asthma07:14

Acupuncture in a Rat Model of Asthma

Published on: August 25, 2020

6.5K
Culture of Bladder Cancer Organoids as Precision Medicine Tools08:39

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Published on: December 28, 2021

5.4K

Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.5K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.3K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.1K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.3K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.3K
Uncertainty in Measurement: Accuracy and Precision03:37

Uncertainty in Measurement: Accuracy and Precision

Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. 
101.0K