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Cardiovascular Risk Factors Associated With Venous Thromboembolism.

John Gregson1, Stephen Kaptoge2,3, Thomas Bolton2,3

  • 1London School of Hygiene and Tropical Medicine, London, United Kingdom.

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|January 17, 2019
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Summary
This summary is machine-generated.

Established cardiovascular risk factors like older age, smoking, and high BMI are linked to increased risk of venous thromboembolism (VTE). These findings highlight key modifiable factors for VTE prevention strategies.

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Area of Science:

  • Cardiovascular Medicine
  • Epidemiology
  • Thrombosis Research

Background:

  • The association between established cardiovascular risk factors and venous thromboembolism (VTE) is not fully understood.
  • Investigating these links is crucial for comprehensive risk assessment and prevention.

Purpose of the Study:

  • To quantify the association of major cardiovascular risk factors with VTE, encompassing deep vein thrombosis and pulmonary embolism.
  • To compare the strength of these associations with those for coronary heart disease (CHD).

Main Methods:

  • Utilized individual participant data from the Emerging Risk Factors Collaboration (ERFC) and UK Biobank.
  • Included over 1 million participants without prior cardiovascular disease, analyzed from 1960-2015/2016.
  • Adjusted hazard ratios (HRs) for age, sex, smoking, diabetes, and BMI.

Main Results:

  • Older age, current smoking, and higher body mass index (BMI) were significantly associated with increased VTE risk across both cohorts.
  • Adiposity showed a stronger association with pulmonary embolism than deep vein thrombosis.
  • These risk factors were generally less strongly associated with VTE compared to coronary heart disease (CHD).

Conclusions:

  • Older age, smoking, and adiposity are consistently linked to a higher risk of venous thromboembolism.
  • These findings reinforce the importance of managing these factors for VTE prevention.
  • Further research is needed to clarify associations with other factors like diabetes and lipids.