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Related Experiment Videos

Nimodipine in migraine prophylaxis.

E Ansell1, T Fazzone, R Festenstein

  • 1City of London Migraine Clinic, UK.

Cephalalgia : an International Journal of Headache
|December 1, 1988
PubMed
Summary

Nimodipine, a calcium channel blocker, was tested against a placebo for headache treatment. The study found no significant difference between nimodipine and placebo in reducing headache frequency, severity, or duration.

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Area of Science:

  • Pharmacology
  • Neurology
  • Clinical Trials

Background:

  • Nimodipine is a calcium channel blocker affecting vascular smooth muscle.
  • Vascular smooth muscle plays a role in various physiological and pathological processes.

Purpose of the Study:

  • To evaluate the efficacy of nimodipine in treating headaches.
  • To compare nimodipine's effects against a placebo in a double-blind trial.

Main Methods:

  • Double-blind, parallel-group study design.
  • 68 patients treated with 40 mg nimodipine thrice daily or placebo.
  • Trial duration of 6 months with most patients completing over 8 weeks.

Main Results:

  • No significant differences observed in headache attack frequency between nimodipine and placebo groups.

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  • No significant differences in headache severity or duration.
  • No significant differences in gastrointestinal or other reported symptoms.

    • Conclusions:

    • Nimodipine did not demonstrate significant efficacy over placebo for headache treatment in this study.
    • Further research may be needed to explore nimodipine's therapeutic potential in other conditions.