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Updated: Jan 30, 2026

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
Published on: January 9, 2020
A web application and service for imputing and visualizing missense variant effect maps
Yingzhou Wu1,2,3,4, Jochen Weile1,2,3,4, Atina G Cote1,4
1Donnelly Centre, University of Toronto, Toronto, ON, Canada.
Summary:
The promise of personalized genomic medicine depends on our ability to assess the functional impact of rare sequence variation. Multiplexed assays can experimentally measure the functional impact of missense variants on a massive scale. However, even after such assays, many missense variants remain poorly measured. Here we describe a software pipeline and application to impute missing information in experimentally determined variant effect maps.
Availability And Implementation:
http://impute.varianteffect.org source code: https://github.com/joewuca/imputation.
Supplementary Information:
Supplementary data are available at Bioinformatics online.
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