Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Evolutionary History?02:35

What is Evolutionary History?

43.4K
Scientists record evolutionary history by analyzing fossil, morphological, and genetic data. The fossil record documents the history of life on Earth and provides evidence for evolution. However, both fossil and living organisms offer evidence that outlines Earth’s evolutionary history.
43.4K
Evolutionary Psychology01:20

Evolutionary Psychology

1.0K
Evolutionary psychology explores the origins of human behavior and mental processes by framing them within the context of natural selection, a theory famously propounded by Charles Darwin. This field asserts that many behaviors common across human societies — ranging from instinctive fear reactions to complex social interactions — arose as evolutionary adaptations. These adaptations enhanced the survival and reproductive success of our ancestors, thereby becoming embedded in the...
1.0K
Criticisms of the Evolutionary Perspective01:23

Criticisms of the Evolutionary Perspective

372
In a study where individuals posing as strangers offered compliments and proposed casual sex to students, the responses differed significantly based on gender. Not a single woman accepted the proposal, while 70% of the men agreed. This outcome provides a useful scenario to explore through the lens of evolutionary psychology and social learning theory, highlighting the diverse perspectives on human sexual behaviors.
Evolutionary psychology provides one explanation for these findings, suggesting...
372
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

7.0K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.0K
Protein-protein Interfaces02:04

Protein-protein Interfaces

14.7K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
14.7K
Protein and Protein Structure02:15

Protein and Protein Structure

87.5K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
87.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy and Safety of Paclitaxel Plus Ramucirumab as Second-Line Therapy in Advanced Gastric Cancer: A Retro-Prospective Single-Centre Study.

The Gulf journal of oncology·2026
Same author

Ultra-Confinement of Polaritons in Single Atomic Layer Ag Photonic Quantum Dots.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Real world experience with cyclin dependent kinase inhibitors in metastatic breast cancer in India.

PloS one·2026
Same author

Comparative Efficacy and Toxicity of Gemcitabine-Cisplatin vs. Gemcitabine-Carboplatin in Metastatic Carcinoma of the Urinary Bladder: A Retrospective Review.

The Gulf journal of oncology·2026
Same author

Case Report | FH-Deficient Uterine Leiomyomas: Pathological Insights into a Rare Tumor.

The Gulf journal of oncology·2026
Same author

Progress and prospects of parasitic plant biodiversity genomics.

Plant & cell physiology·2026

Related Experiment Video

Updated: Jan 30, 2026

Atomically Traceable Nanostructure Fabrication
12:35

Atomically Traceable Nanostructure Fabrication

Published on: July 17, 2015

9.2K

The Evolutionary Traceability of a Protein.

Arpit Jain1, Dominik Perisa1, Fabian Fliedner1

  • 1Applied Bioinformatics Group, Institute of Cell Biology & Neuroscience, Goethe University, Frankfurt, Germany.

Genome Biology and Evolution
|January 17, 2019
PubMed
Summary
This summary is machine-generated.

We introduce evolutionary traceability to measure how far back in time gene orthologs can be reliably detected. High traceability genes are ancient, while low traceability genes may be missed in evolutionary reconstructions.

Keywords:
LUCAmetabolic pathwayortholog searchphylogenetic profilesequence evolutiontwilight zone

More Related Videos

Spatial Multiobjective Optimization of Agricultural Conservation Practices using a SWAT Model and an Evolutionary Algorithm
11:53

Spatial Multiobjective Optimization of Agricultural Conservation Practices using a SWAT Model and an Evolutionary Algorithm

Published on: December 9, 2012

13.5K
Isolation and Analysis of Traceable and Functionalized Extracellular Vesicles from the Plasma and Solid Tissues
09:57

Isolation and Analysis of Traceable and Functionalized Extracellular Vesicles from the Plasma and Solid Tissues

Published on: October 17, 2022

2.8K

Related Experiment Videos

Last Updated: Jan 30, 2026

Atomically Traceable Nanostructure Fabrication
12:35

Atomically Traceable Nanostructure Fabrication

Published on: July 17, 2015

9.2K
Spatial Multiobjective Optimization of Agricultural Conservation Practices using a SWAT Model and an Evolutionary Algorithm
11:53

Spatial Multiobjective Optimization of Agricultural Conservation Practices using a SWAT Model and an Evolutionary Algorithm

Published on: December 9, 2012

13.5K
Isolation and Analysis of Traceable and Functionalized Extracellular Vesicles from the Plasma and Solid Tissues
09:57

Isolation and Analysis of Traceable and Functionalized Extracellular Vesicles from the Plasma and Solid Tissues

Published on: October 17, 2022

2.8K

Area of Science:

  • Genomics
  • Evolutionary Biology
  • Bioinformatics

Background:

  • Ortholog similarity decays over time, limiting ancient gene set reconstruction.
  • Inferring common ancestry becomes challenging as evolutionary distance increases.

Purpose of the Study:

  • Introduce "evolutionary traceability" to quantify detectable evolutionary distance for proteins.
  • Improve accuracy of ancient gene set reconstructions and understanding of gene evolution.

Main Methods:

  • Developed "evolutionary traceability" as a novel metric.
  • Applied the metric to yeast genomes to assess gene origins.
  • Utilized the "protTrace" software tool for calculations.

Main Results:

  • Genes with high traceability in yeast are linked to core functions like catalysis and ion transport.
  • Genes with low traceability are enriched for regulatory functions.
  • Traceability analysis identified missed orthologs in fast-evolving organisms like microsporidia.

Conclusions:

  • Evolutionary traceability distinguishes true gene absence from detection limitations.
  • This metric enhances understanding of functional protein network conservation.
  • The protTrace software facilitates improved evolutionary analyses.