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Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Advances in multidisciplinary therapy for meningiomas.

Priscilla K Brastianos¹, Evanthia Galanis², Nicholas Butowski³

¹Divisions of Hematology/Oncology & Neuro-Oncology, Departments of Medicine & Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.

|January 17, 2019

Summary

Surgery is the primary treatment for meningiomas, but recurrences occur. Adjuvant radiation therapy shows promise for high-risk cases, while systemic therapies are under investigation for recurrent meningiomas.

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Area of Science:

Neurosurgery
Radiation Oncology
Medical Oncology

Background:

Surgery is the standard first-line treatment for symptomatic and enlarging meningiomas, based on retrospective data.
Aggressive meningiomas can recur early after resection, posing treatment challenges and risks of neurological injury.
Radiation therapy is a complementary strategy with promising preliminary results from cooperative group studies in higher-risk meningiomas.

Purpose of the Study:

To review current treatment strategies for meningiomas.
To highlight the role of surgery, radiation therapy, and emerging systemic therapies.
To discuss the challenges in managing aggressive and recurrent meningiomas.

Main Methods:

Review of existing literature on meningioma treatment.
Analysis of retrospective case series and cooperative group studies (RTOG 0539, EORTC 22042).
Discussion of ongoing clinical trials for systemic therapies.

Main Results:

Surgery is effective but a subset of meningiomas recur aggressively.
Adjuvant radiation therapy shows promising preliminary results in higher-risk meningiomas.
Systemic therapies have historically yielded disappointing results but novel agents are being evaluated.

Conclusions:

Surgery remains the cornerstone for meningioma treatment.
Adjuvant radiation therapy is a viable option for higher-risk meningiomas.
Novel systemic therapies offer future hope for recurrent and aggressive meningiomas.